Question
Is high-flow nasal cannula noninferior to noninvasive ventilation
for preventing reintubation and postextubation respiratory failure?
Findings
In this multicenter randomized noninferiority clinical trial that
included 604 adults, the proportion requiring reintubation was 22.8%
with high-flow therapy vs 19.1% with noninvasive ventilation, and
postextubation respiratory failure was observed in 26.9% with
high-flow therapy vs 39.8% with noninvasive ventilation, reaching the
noninferiority threshold.
Meaning
High-flow nasal cannula immediately after scheduled extubation was
not inferior to noninvasive mechanical ventilation for risk of
reintubation and postextubation respiratory failure in patients at
high risk of reintubation.
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