Abstract
Influenza activity
in the United States was low during October 2017, but has been
increasing since the beginning of November. Influenza A viruses have
been most commonly identified, with influenza A(H3N2) viruses
predominating. Several influenza activity indicators were higher than
is typically seen for this time of year. The majority of influenza
viruses characterized during this period were genetically or
antigenically similar to the 2017-18 Northern Hemisphere cell-grown
vaccine reference viruses. These data indicate that currently
circulating viruses have not undergone significant antigenic drift;
however, circulating A(H3N2) viruses are antigenically less similar
to egg-grown A(H3N2) viruses used for producing the majority of
influenza vaccines in the United States. It is difficult to predict
which influenza viruses will predominate in the 2017-18 influenza
season; however, in recent past seasons in which A(H3N2) viruses
predominated, hospitalizations and deaths were more common, and the
effectiveness of the vaccine was lower. Annual influenza vaccination
is recommended for all persons aged greater than or equal to 6 months
who do not have contraindications. Multiple influenza vaccines are
approved and recommended for use during the 2017-18 season, and
vaccination should continue to be offered as long as influenza
viruses are circulating and unexpired vaccine is available. This
report summarizes U.S. influenza activity* during October 1-November
25, 2017 (surveillance weeks 40-47).
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