Background
Longitudinal
analyses of large, detailed adult critical care data
sets provide
insights into practice trends and generate useful outcome and process
benchmarks.
Methods
Data representing
991,571 consecutive critical care visits to 160 US adult ICUs from
2009 to 2013 from the eICU Research Institute clinical practice
database were used to quantitate patient characteristics, APACHE
IV–based acuity predictions, treatments, and outcomes. Analyses for
changes over time were performed for patient characteristics, entry
and discharge locations, primary admission diagnosis, treatments,
adherence to consensus ICU best practices, length of stay (LOS), and
inpatient mortality.
Results
We detected
significant trends for increasing age, BMI, and risk of mortality,
higher frequency of admission from an ED and stepdown unit, and more
frequent hospital discharge to substance abuse centers and skilled
nursing facilities. Significantly more patients were admitted for
sepsis, emphysema, coma, congestive heart failure, diabetic
ketoacidosis, and fewer were admitted for asthma, unspecified chest
pain, coronary artery bypass graft, and stroke care. The frequency of
noninvasive mechanical ventilation and adherence to critical care
best practices significantly increased, whereas the duration of renal
replacement therapies, frequency of transfusions, antimicrobial use,
critical care complications, LOS, and inpatient mortality decreased.
Conclusions
Analyses of
patients, practices, and outcomes from a large geographically
dispersed sample of adult ICUs revealed trends of increasing age and
acuity, higher rates of adherence to best practice, use of
noninvasive mechanical ventilation, and decreased use of
antimicrobials, transfusions, and duration of renal replacement
therapies. Acuity-adjusted LOS and in hospital mortality decreased.
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