Background
Acute venous
thromboembolism leads to significant morbidity and mortality.
Advances in pharmacotherapy facilitate outpatient care in low-risk
acute venous thromboembolism. The proportion of hospitalized acute
venous thromboembolism cases and the average length of stay are not
known. We sought to identify predictors of hospitalization, changes
in hospitalization rates and length of stay of acute venous
thromboembolism over a decade in Alberta, Canada.
Methods
Using linked
administrative health databases, we identified adult patients
diagnosed primarily with acute venous thromboembolism between April
2002 and March 2012. We measured trends using Poisson regression,
adjusted length of stay using analysis of covariance. We identified
predictors of hospitalization using multivariate logistic regression.
Results
8198 out of 31,656
acute venous thromboembolism cases were hospitalized. The overall
venous thromboembolism admission rates ranged between 23.7% and 27.8%
with no evident temporal trend (P = 0.10). The average admission
rate was 51.9% for pulmonary embolism and 16.1% for deep vein
thrombosis. The mean length of stay for deep vein thrombosis and
pulmonary embolism remained unchanged with an adjusted mean for
venous thromboembolism of 6.9 ± 1.0 days. Higher Charlson
index, older age, male gender, pulmonary embolism at presentation and
multiple comorbidities were associated with hospitalization.
Hospitalization was associated with 30-day mortality (odds ratio:2.8,
95% CI: 2.2–3.5) whereas the length of stay was not (odds
ratio:1.0, 95% CI: 0.99–1.0).
Conclusion
Hospitalization
rates and mean length of stay for acute venous thromboembolism did
not change significantly between 2002 and 2012. Advances in
pharmacotherapy have not yet reduced hospitalization rates or length
of stay for venous thromboembolism.
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