Sunday, December 16, 2018

PE diagnosis and rule out

From the article:


•Pulmonary embolism (PE) is simultaneously one of the most overtested yet underdiagnosed diseases.
•Even with reasonable and prudent care, some cases of PE will be missed.
•Clinicians must use gestalt and intuition to decide whether to start testing for PE.
•Clinicians should use the D-dimer more often.
•Know the image quality of computed tomography when ruling out PE with a high pretest probability.



Failure to test for pulmonary embolism (PE) can be a lethal mistake, but PE and produces symptoms similar to many other diseases. Overtesting for PE has negative consequences.


Use published evidence to create a rationale and safe diagnostic approach for ambulatory and emergency patients with suspected PE in 2017.


Pulmonary embolism need not be pursued in patients with no symptoms of PE in the present or recent history (dyspnea, chest pain, cough or syncope), and always normal vital signs. When clinicians have a low clinical suspicion for PE or a Wells score less than 2, they can reasonably exclude PE with the Pulmonary Embolism Rule out Criteria (PERC rule). For patients with a “PE-unlikely” pretest probability (Wells or simplified revised Geneva score less than 5), PE can be ruled out with a normal or age-adjusted D-dimer concentrations. Other patients should undergo pulmonary vascular imaging, and the choices are discussed, including computerized tomographic pulmonary angiography, planar and single-photon emission computed tomography (SPECT).


A thoughtful algorithm for PE exclusion and diagnosis requires pretest probability assessment in all patients, followed by selective use of clinical criteria, the quantitative D-dimer, and pulmonary vascular imaging.

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