This is a hot topic in hospital medicine. I’ve discussed the tension between “patient oriented” and “disease oriented” medical literature. In my opinion we need to read both. Here’s a patient oriented review of intensive in patient insulin therapy from last October’s Cleveland Clinic Journal of Medicine. Here is a disease oriented study and an accompanying editorial from a recent issue of the Journal of Clinical Investigation.
For me, empirical evidence is more interesting and meaningful when coupled with pathophysiologic rationale. (I hope the EBM Mafia isn’t watching).