Although it ought to be straightforward, several controversies regarding treatment of hypothyroidism have arisen in the past decade. These are covered in a review in the July/August 2006 issue of The Endocrinologist.
What is the optimal TSH target during treatment? 0.4 to 2.5 mIU/L.
Is T4 + T3 replacement superior to T4 replacement alone? No.
Is brand L-thyroxine superior to generic? Not according to the best available evidence.
Should subclinical hypothyroidism be treated? Probably not if the TSH is less than 10 mIU/L.