More on NSAIDs and cardiovascular risk

The portrayal of COX-2 inhibiting NSAIDs as cardiotoxic and older NSAIDs as safe is simplistic and irresponsible, as I demonstrated here. Now there’s this study, published ahead of print in the Annals of Rheumatic Disease on line, suggesting that ibuprofen is associated with higher cardiovascular risk, over 8 fold in high risk aspirin users, than the COX-2 inhibitor lumiracoxib.