After four evidence-based protocols were introduced in their ICU (lung protective strategy for acute lung injury, activated protein C for severe sepsis/septic shock, intravenous insulin for hyperglycemia control and a protocol for sedation/analgesia) Mayo Clinic investigators reported a reduction in mortality. “Using the pre-protocol period as a reference, the severity-adjusted risk (95% confidence interval) of dying was 0.777 (0.655 – 0.922) during the protocol period (P = 0.0038).”
The impact of introducing multiple protocols in critically ill patients had not previously been well studied. Via BMC Emergency Medicine.
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