Monday, March 22, 2010

Statins and liver disease---how big a problem?

From Seminars in Liver Disease:

Despite their widespread use, acute liver failure and death have rarely been reported in patients with statin hepatotoxicity. Multiple retrospective studies as well as a large prospective randomized controlled trial demonstrate that statins can safely be given to hyperlipidemic patients with compensated chronic liver disease.

1 comment:

Michael Kirsch, M.D. said...

Many of the patients who need hypolipidemic medications have hepatic steatosis with mild elevations of the serum transaminase values. These patients are certainly eligible for statins, with proper monitoring, although primary physicians sometimes are spooked by the enzymes.