This open-label randomized controlled trial reported a reduction in PTS attributable to local thrombolytic therapy in patients with iliofemoral DVT. The NNT was 7 and there was a downside of bleeding. The authors recommend the treatment, on top of conventional anticoagulant therapy, for patients with upper thigh DVT extending into the iliac, if appropriate expertise is available at the treating institution.
Medscape commentary here.
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