Tuesday, August 13, 2013

Carbapenem-resistant gram negative infections: treatment update

Here's another review, available as free full text via Medscape.

High level data are lacking but what studies we have suggest the following take home points:

Candidate antibiotics include aminoglycosides, tygecycline, colistin and, yes, carbapenems.

Two or three drug combination therapy is advised over monotherapy.

Despite the fact that these are carbapenemase producing infections outcomes are better when a carbapenem (meropenem is the best studied) is included in the regimen.

Some promising gram negative agents are in the pipeline. Finally.

No comments: