This recently emerging entity is the
topic of a review in the Cleveland Clinic Journal of Medicine.
Some points of interest:
The principal cause is autoantibody to
HMG coenzyme A reductase, the site of action of statins.
Unlike other statin associated
myopathies it does not resolve with stopping the drug and requires
immunosuppression.
In the spectrum of statin associated
myopathy three principal entities have emerged: 1) simple myalgias
without CK elevation; 2) myositis with elevated CK which resolves on
drug discontinuation; and 3) the autoimmune entity just described.
No comments:
Post a Comment