Early goal directed therapy for sepsis---fatally flawed???

That’s what these guys, writing in the American Journal of Emergency Medicine, think. The basis for their objections? Essentially two fold: theoretical (e.g. CVP is not a good surrogate for assessing volume resuscitation) and the fact that while this “bundle within the sepsis bundle” has been shown to save lives, its individual components have not been evaluated separately. That issue is being addressed, at least partially, in three currently ongoing clinical trials.