Probably not but it
is at least worse with warfarin. Here’s the latest comparative study. The reason? Although all anticoagulants have a common
mechanism (intraglomerular and intratubular hemorrhage) warfarin has
a second one. It promotes vascular calcification in the kidney. It does this by inhibiting the local carboxylation of certain vascular protective proteins. But there’s even more to it than
that. NOACs, by their inhibition of factors II and X, may be
vascular protective because these clotting factors are involved in
vascular inflammation, according to the audio summary for the JACC
article linked above.
No comments:
Post a Comment