Monday, May 05, 2008

Alpha-1 antitrypsin deficiency

This topic was updated in a recent issue of the American Journal of Medicine.

Key points:

The condition is under diagnosed, and all patients with COPD should be screened once in their lifetime.

Liver disease is due to accumulation of abnormal antitrypsin molecules in hepatocytes.

Unusual disease associations include Wegener’s granulomatosis, aneurysms and necrotizing panniculitis.

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