Allopurinol hypersensitivity syndrome
---is characterized by severe dermatologic manifestations and sometimes multiorgan failure. It is believed to be due to accumulation of a metabolite and may be dose related. Risk can be decreased by following labeling recommendations for dose adjustment in renal failure, but such recommendations are often ignored. A case summary and brief review are presented in the American Journal of Medicine.
1 comment:
Is the rash in Allopurinol hypersensitivity syndrome pruritic? Do they blanch on application of pressure?
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