Since Dr. Nissen's meta-analysis showing risk with Avandia that is fraught with controversy, we have had multiple large, prospective, randomized clinical trials that show the opposite result. Between RECORD, ADOPT, DREAM, ACCORD and VADT;
there have been over 26,000 patients studied for over 3.5 years, of which more than 15,000 patients took Avandia and showed absolutely no difference in heart attacks or myocardial ischemia.
Maybe we were misled by Nissen’s meta-analysis. What’s even more unfortunate is the way the results were hyped and alternative explanations for the findings summarily rejected.
Via Kevin M.D.