Thursday, August 28, 2008

Vancomycin nephrotoxicity---an emerging concern

Since the publication of dosing recommendations for trough vancomycin levels of 15-20mg/l it appears we’ve been pushing the envelope of nephrotoxicity. Some clinicians are pushing doses as high as 4 g/day. Such doses are associated with nephrotoxicity according to this recent cohort study published in Antimicrobial Agents and Chemotherapy.

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