Platelet transfusions in critically ill patients: a review

A systematic review in the journal Blood concluded:

Recommendation: For critically ill adults with severe thrombocytopenia and no evidence of bleeding, there is insufficient evidence to make a recommendation for or against platelet transfusion.

However, the authors cite the Surviving Sepsis guidelines which made a weak recommendation for prophylactic platelet transfusion in patients with platelet counts below 20,000 who have significant bleeding risk.