Saturday, March 29, 2014
Sideroblastic anemia induced by linezolid
This report makes a pretty convincing case that it's a real entity. I was a bit surprised the article didn't mention vitamin B6, which has a connection. Rare cases of B6 responsive sideroblastic anemia (of a variety of causes) were reported in the 1950s and 60s but soon fell off the radar screen. In more recent years reports have surfaced of B6 responsive anemia (but not other cytopenias) in patients taking linezolid. Those reports, at least the ones I have seen, do not mention sideroblasts.