Monday, March 02, 2015

Systematic review on treatment of calcium blocker overdose

Free full text here.

Academic Life in Emergency Medicine summarizes the review:

A few findings from the systematic review:

The majority of literature on calcium channel blocker overdose management is heterogenous, biased, and low-quality evidence.

Interventions with the strongest evidence are high-dose insulin and extracorporeal life support.

Interventions with less evidence, but still possibly beneficial, include calcium, dopamine, norepinephrine, 4-aminopyridine (where available), and lipid emulsion therapy.

Stay tuned for the international guideline coming out soon. One treatment recommendation from the new guideline, reported at the 8th European Congress on Emergency Medicine September 2014, is not to use glucagon.

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