Thursday, May 22, 2008

Allopurinol hypersensitivity syndrome

---is characterized by severe dermatologic manifestations and sometimes multiorgan failure. It is believed to be due to accumulation of a metabolite and may be dose related. Risk can be decreased by following labeling recommendations for dose adjustment in renal failure, but such recommendations are often ignored. A case summary and brief review are presented in the American Journal of Medicine.

1 comment:

Anonymous said...

Is the rash in Allopurinol hypersensitivity syndrome pruritic? Do they blanch on application of pressure?