Ceftobiprole medocaril is an extended-spectrum cephalosporin with activity against methicillin-resistant Staphylococcus spp., vancomycin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecalis, Enterobacteriaceae, and Pseudomonas aeruginosa.
The major hole in this 5th generation cephalosporin? Those pesky ESBLs.
Note: Many VREs are Enterococcus faecium. Ceftobiprole is apparently not active against E. faecium.
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