Ammonia is instrumental in the pathogenesis. It’s not just a marker.
Ammonia causes astrocyte swelling and alterations in neurotransmitter metabolism.
Cytokines cause astrocyte swelling, explaining the role of infection in precipitating HE.
Those are some of the interesting points in a review published in Seminars in Liver Disease, one of the better reviews I’ve seen on the subject.
No comments:
Post a Comment