Acute liver failure (ALF) is defined as the development of impaired hepatic synthetic function with coagulopathy and the development of hepatic encephalopathy in the absence of underlying liver disease in less than 2 to 3 months time.[1] In the setting of ALF, hepatic encephalopathy may be associated with life-threatening cerebral edema, whereas by contrast this association is absent in patients who have chronic liver failure with encephalopathy.
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