Saturday, January 04, 2014

Thiamine administration as a treatment for heart failure with reduced ejection fraction

This systematic review and meta-analysis found two placebo controlled randomized trials. Both showed that thiamine administration was associated with improvement in EF but the numbers were small. The review cites this paper which reports an alarming prevalence of thiamine deficiency in heart failure patients.

Here is another systematic review supporting thiamine administration. Its selection criteria for included studies were broader. Larger studies are needed.

No comments: