It’s old and off label, but is emerging as the best treatment.
CCJM review.
CCJM editorial outlining precautions against adverse effects.
The COPE trial.
Wednesday, May 30, 2007
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- R. W. Donnell
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1 comments:
Although colchicine can be used safely, it has a very narrow therapeutic index. Therefore, patients must be carefully counseled about the early warning signs of toxicity (nausea, abdominal pain or diarrhea). Such patients require drug dosing interruption or, at least, dose reductions or they may run into more serious toxicity, which includes multi-organ failure and death.
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