Although colchicine can be used safely, it has a very narrow therapeutic index. Therefore, patients must be carefully counseled about the early warning signs of toxicity (nausea, abdominal pain or diarrhea). Such patients require drug dosing interruption or, at least, dose reductions or they may run into more serious toxicity, which includes multi-organ failure and death.
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Although colchicine can be used safely, it has a very narrow therapeutic index. Therefore, patients must be carefully counseled about the early warning signs of toxicity (nausea, abdominal pain or diarrhea). Such patients require drug dosing interruption or, at least, dose reductions or they may run into more serious toxicity, which includes multi-organ failure and death.
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