Wednesday, May 09, 2007

MTHFR testing to assess risk of VTE recurrence---don’t bother

The MTHFR 677C-T polymorphism increases homocysteine levels. Meta-analyses have demonstrated a weak association of the 677TT genotype with risk of VTE, although these data may be troubled by publication bias. In this large population-based case-control study the genotype was not associated with increased risk of recurrence. MTHFR gene testing is not recommended although homocysteine testing is reasonable.

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