Klebsiella pneumoniae Carbapenemases---mediators of emerging gram negative resistance

Klebsiella pneumoniae carbapenemases (KPCs) cause resistance not only in Klebsiella, but also in other gram negatives. The topic is reviewed in a Medscape Infectious Disease Expert Column. Tigecycline may be the best option but experience is limited. Polymixins are agents of last resort. The role, if any, of quinolones and aminoglycosides was not mentioned. I don’t know of anything in the pipeline.