Wednesday, March 25, 2009

The long awaited NICE-SUGAR results

---won’t seem very nice if you’re an advocate for tight glucose control in critically ill patients:

Conclusions In this large, international, randomized trial, we found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg per deciliter.

The Surviving Sepsis Guideline authors, aware of the lack of evidence for a specific glycemic target, made a reasonable guess at a recommendation of 150mg/dl. I think they made a pretty good guess.

(Retired Doc beat me to it with this insightful post).

No comments: