Thursday, June 30, 2016

Proton pump inhibitors and eosinophilic esophagitis

The question is addressed in this paper. Although EO is in general unresponsive to PPIs there is a subset that is:

Gastro-oesophageal reflux disease (GORD) is the most common oesophageal disorder, whereas eosinophilic oesophagitis (EoE) is an emerging disease unresponsive to PPI therapy. Updated guidelines in 2011 described proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE), a novel phenotype in EoE patients who were responsive to PPIs.

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