Saturday, November 17, 2007

Fondaparinux and HIT---the bubble has burst

It only takes one counter-example to disprove an absolute statement like “fondaparinux (Arixtra) never causes HIT”. We now have a counter-example in the form of a letter to the editor of NEJM which documents a case of HIT due to fondaparinux. So much for its emergence as a treatment for HIT!

H/T to the Mayo Hospital Medidine update!

2 comments:

Anonymous said...

A single letter to the NEJM doesn't warrant a change in the standard of care. We need more data, not more opining.

Donald Sweet, MD, FACP

Robert W Donnell said...

Of course it doesn't. But Arixtra never was the standard of care for HIT.