Real world experience with early goal directed therapy for sepsis

Here’s how they did it at the Carolinas Medical Center. Although the investigators observed a 33% RRR similar to that reported in the original study by Rivers, their study was time limited and not powered to reach statistical significance.

The Carolinas Medical Center protocol was an ER based protocol. That is, the initial assessment for patient eligibility, insertion of the central venous catheter, initial hemodynamic management and antibiotic initiation were done by ER personnel before admission to the ICU.