A non-steroidal anti-inflammatory drug, diclofenac, failed to reduce fluid accumulation around the heart after cardiac surgery.
The NSAID after heart surgery also did not reduce the serious problem of cardiac tamponade, compression of the heart by fluid.
Only patients with pericardial effusion at baseline were enrolled. The investigators concluded:
The use of NSAIDs in post-cardiac surgery patients is useless in this setting.
As pointed out in the presentation slides NSAID use post CABG has been common even though not supported by good evidence, and in spite of known adverse effects including increased renal failure, heart failure and myocardial infarction.