Monday, January 25, 2010

DIC correlates with lactate levels in sepsis

---at least when the balance is shifted toward microthrombosis:

Our observations show that, in the course of human septic shock, activation of coagulation and, particularly, inhibition of activated fibrinolysis are independently associated with hyperlactatemia. This suggests a contribution of DIC resulting from a coagulation/fibrinolysis imbalance to microvascular obstruction, tissue hypoxygenation and thereby to ultimate demise.

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