Drug induced acute liver injury

An excellent review was recently published in Seminars in Liver Disease. Free full text access is available via Medscape.

Points of interest:

Prognosis is largely determined by the presence or absence of coagulopathy and encephalopathy. Transplant free survival is poor if these are present.

Acetaminophen is the most frequent culprit.

N-acetylcysteine therapy may benefit some patients with non-acetaminophen induced injury.